Toxicity study in naïve mice

The Federal Agency for Disruptive Innovation - SPRIND GmbH ("SPRIND") - aims to cre-ate new disruptive innovations from Germany. That means products, services and sys-tems that make all our lives noticeably and sustainably better. To achieve this, SPRIND brings together new thinkers from science and business, people with outstanding ideas, …

CPV: 73000000 FoU-tjänster samt tillhörande konsulttjänster
Sista ansökningsdag:
12 november 2025 11:00
Typ av tidsfrist:
Inlämnande av anbud
Plats för avrättning:
Toxicity study in naïve mice
Plats för tilldelning:
BiconY Therapeutics GmbH
Tilldelningsnummer:
BiconY 01/2025

1. Buyer

1.1 Buyer

Official name : BiconY Therapeutics GmbH
Legal type of the buyer : Public undertaking, controlled by a central government authority
Activity of the contracting authority : Economic affairs

2. Procedure

2.1 Procedure

Title : Toxicity study in naïve mice
Description : The Federal Agency for Disruptive Innovation - SPRIND GmbH ("SPRIND") - aims to cre-ate new disruptive innovations from Germany. That means products, services and sys-tems that make all our lives noticeably and sustainably better. To achieve this, SPRIND brings together new thinkers from science and business, people with outstanding ideas, special expertise, and passion. Hence, SPRIND provides an entrepreneurial environment that turns ideas into reality. The objective of BiconY Therapeutics GmbH, a SPRIND subsidiary, is the development of a bispecific antibody combination for the treatment of solid tumours. The combination con-sists of proprietary, bispecific CD3 anti-bodies (bsAbCD3) and bispecific CD28 co-stimulators (BiCos), which, when used together, significantly im-prove the specificity, sus-tainability, and efficiency of a T cell recruitment and thus the immune response against tumour cells. The aim of the research and development activities is to provide proof of concept for the effect of bispecific antibody therapy in the form of two phase I/IIa clinical trials. For the IND application at Paul Ehrlich Institute (Germany) we have to show safety of our molecules in animal models. Following extensive discussions and thorough analyses, the PEI has granted approval for a comprehensive toxicological study of our lead candidate in mice. Therefore, we are looking for a service provider to support us regarding pharmaco-toxicological studies
Procedure identifier : 06e49d9a-34f3-43b1-bba8-231891425772
Internal identifier : BiconY 01/2025
Type of procedure : Open
The procedure is accelerated : no

2.1.1 Purpose

Main nature of the contract : Services
Main classification ( cpv ): 73000000 Research and development services and related consultancy services

2.1.2 Place of performance

Anywhere in the European Economic Area

2.1.2 Place of performance

Country : Switzerland
Anywhere in the given country

2.1.2 Place of performance

Country : United Kingdom
Anywhere in the given country

2.1.2 Place of performance

Country : United States
Anywhere in the given country

2.1.2 Place of performance

Country : Canada
Anywhere in the given country

2.1.4 General information

Additional information : #Bekanntmachungs-ID: CXP4D9L52LD#
Legal basis :
Directive 2014/24/EU
vgv -

2.1.6 Grounds for exclusion

Sources of grounds for exclusion : Notice, Procurement Document
Breaching of obligations set under purely national exclusion grounds : In accordance with §§ 123,124 GWB, § 22 LkSG
Participation in a criminal organisation :
Terrorist offences or offences linked to terrorist activities :
Money laundering or terrorist financing :
Fraud :
Corruption :
Child labour and including other forms of trafficking in human beings :
Breaching obligation relating to payment of taxes :
Breaching obligation relating to payment of social security contributions :
Breaching of obligations in the fields of environmental law :
Breaching of obligations in the fields of social law :
Breaching of obligations in the fields of labour law :
Insolvency :
Assets being administered by liquidator :
Business activities are suspended :
Analogous situation like bankruptcy, insolvency or arrangement with creditors under national law :
Grave professional misconduct :
Agreements with other economic operators aimed at distorting competition :
Conflict of interest due to its participation in the procurement procedure :
Direct or indirect involvement in the preparation of this procurement procedure :
Early termination, damages, or other comparable sanctions :
Misrepresentation, withheld information, unable to provide required documents and obtained confidential information of this procedure :

5. Lot

5.1 Lot technical ID : LOT-0001

Title : Toxicity study in naïve mice
Description : The Federal Agency for Disruptive Innovation - SPRIND GmbH ("SPRIND") - aims to cre-ate new disruptive innovations from Germany. That means products, services and sys-tems that make all our lives noticeably and sustainably better. To achieve this, SPRIND brings together new thinkers from science and business, people with outstanding ideas, special expertise, and passion. Hence, SPRIND provides an entrepreneurial environment that turns ideas into reality. The objective of BiconY Therapeutics GmbH, a SPRIND subsidiary, is the development of a bispecific antibody combination for the treatment of solid tumours. The combination con-sists of proprietary, bispecific CD3 anti-bodies (bsAbCD3) and bispecific CD28 co-stimulators (BiCos), which, when used together, significantly im-prove the specificity, sus-tainability, and efficiency of a T cell recruitment and thus the immune response against tumour cells. The aim of the research and development activities is to provide proof of concept for the effect of bispecific antibody therapy in the form of two phase I/IIa clinical trials. For the IND application at Paul Ehrlich Institute (Germany) we have to show safety of our molecules in animal models. Following extensive discussions and thorough analyses, the PEI has granted approval for a comprehensive toxicological study of our lead candidate in mice. Therefore, we are looking for a service provider to support us regarding pharmaco-toxicological studies
Internal identifier : BiconY 01/2025

5.1.1 Purpose

Main nature of the contract : Services
Main classification ( cpv ): 73000000 Research and development services and related consultancy services

5.1.2 Place of performance

Anywhere in the European Economic Area
Additional information :

5.1.2 Place of performance

Country : Switzerland
Anywhere in the given country
Additional information :

5.1.2 Place of performance

Country : United Kingdom
Anywhere in the given country
Additional information :

5.1.2 Place of performance

Country : United States
Anywhere in the given country
Additional information :

5.1.2 Place of performance

Country : Canada
Anywhere in the given country
Additional information :

5.1.3 Estimated duration

Start date : 01/12/2025
Duration end date : 29/05/2026

5.1.4 Renewal

Maximum renewals : 2
Other information about renewals : The contracting entity may extend the contract twice.

5.1.6 General information

Reserved participation : Participation is not reserved.
Procurement Project not financed with EU Funds.
The procurement is covered by the Government Procurement Agreement (GPA) : yes
This procurement is also suitable for small and medium-sized enterprises (SMEs) : no

5.1.7 Strategic procurement

Aim of strategic procurement : No strategic procurement

5.1.9 Selection criteria

Sources of selection criteria : Notice
Criterion : References on specified services
Description : Experience with toxicological studies in mice (minmum 5 reference projects since 1 October 2022).
Criterion : Study, technical and research facilities
Description : 3 Audit results from pharma companies or/and regulatory agencies (the last three audits must be specified, whereby the last audit must not be older than 1 October 2022.)
Criterion : Authorisation or membership of a particular organisation needed for service contracts
Description : Declaration that the following requirements are met: GLP Certificate: issued by EMA (European Medicines Agency) or internationally recognized equivalent. If more than one facility is involved, a separate GLP certifi-cate needs to be available for each.

5.1.11 Procurement documents

Languages in which the procurement documents are officially available : English
Deadline for requesting additional information : 03/11/2025 23:59 +01:00
Ad hoc communication channel :
Name : All communication takes place in English via communication tool in the project area of the procurement portal DTVP.

5.1.12 Terms of procurement

Terms of submission :
Electronic submission : Required
Languages in which tenders or requests to participate may be submitted : German, English
Electronic catalogue : Not allowed
Variants : Not allowed
Tenderers may submit more than one tender : Not allowed
Deadline for receipt of tenders : 12/11/2025 11:00 +01:00
Deadline until which the tender must remain valid : 6 Week
Information that can be supplemented after the submission deadline :
At the discretion of the buyer, all missing tenderer-related documents may be submitted later.
Additional information : Bicony asks - within its discretion - the bidder to submit, complete or correct documents, within the framework laid down by law.
Information about public opening :
Opening date : 12/11/2025 11:01 +01:00
Terms of contract :
The execution of the contract must be performed within the framework of sheltered employment programmes : No
Conditions relating to the performance of the contract : Compliance with the European Union Directive (2010/63/ EU) and the relevant implemented national law or if this EU Directive is not applicable to the bidder/bidding consortium the relevant comparable rules Place of performance The place of performance must be in EU/EEA including Switzerland, UK, USA and/or Canada.
Electronic invoicing : Required
Electronic ordering will be used : no
Electronic payment will be used : yes

5.1.15 Techniques

Framework agreement :
No framework agreement
Information about the dynamic purchasing system :
No dynamic purchase system

5.1.16 Further information, mediation and review

Review organisation : Vergabekammer des Budnes
Information about review deadlines : According to Article 160, Section 3 of the German Act Against Restraint of Competition (GWB), application for review is not permissible insofar as 1. the applicant has identified the claimed infringement of the procurement rules before submitting the application for review and has not submitted a complaint to the contracting authority within a period of 10 calendar days; the expiry of the period pursuant to Article 134, Section 2 remains unaffected, 2. complaints of infringements of procurement rules that are evident in the tender notice are not submitted to the contracting authority at the latest by the expiry of the deadline for the application or by the deadline for the submission of bids, specified in the tender notice. 3. complaints of infringements of procurement rules that first become evident in the tender documents are not submitted to the contracting authority at the latest by the expiry of the deadline for application or by the deadline for the submission of bids, 4. more than 15 calendar days have expired since receipt of notification from the contracting authority that it is unwilling to redress the complaint. Sentence 1 does not apply in the case of an application to determine the invalidity of the contract in accordance with Article 135, Section 1 (2). Article 134, Section 1, Sentence 2 remains unaffected.
Organisation providing additional information about the procurement procedure : BiconY Therapeutics GmbH
Organisation receiving requests to participate : BiconY Therapeutics GmbH

8. Organisations

8.1 ORG-0001

Official name : BiconY Therapeutics GmbH
Registration number : HRB 41594
Postal address : Lagerhofstraße 4
Town : Leipzig
Postcode : 04103
Country subdivision (NUTS) : Leipzig, Kreisfreie Stadt ( DED51 )
Country : Germany
Telephone : +49 69 7191890-12
Roles of this organisation :
Buyer
Organisation providing additional information about the procurement procedure
Organisation receiving requests to participate

8.1 ORG-0002

Official name : Vergabekammer des Budnes
Registration number : 022894990
Postal address : Kaiser-Friedrich-Straße 16
Town : Bonn
Postcode : 53113
Country subdivision (NUTS) : Bonn, Kreisfreie Stadt ( DEA22 )
Country : Germany
Contact point : Vergabekammer des Bundes beim Bundeskartellamt
Fax : +492289499163
Roles of this organisation :
Review organisation

8.1 ORG-0003

Official name : Datenservice Öffentlicher Einkauf (in Verantwortung des Beschaffungsamts des BMI)
Registration number : 0204:994-DOEVD-83
Town : Bonn
Postcode : 53119
Country subdivision (NUTS) : Bonn, Kreisfreie Stadt ( DEA22 )
Country : Germany
Telephone : +49228996100
Roles of this organisation :
TED eSender

Notice information

Notice identifier/version : 8de2fa12-19b5-4f09-9cd3-5cc7352a920e - 01
Form type : Competition
Notice type : Contract or concession notice – standard regime
Notice dispatch date : 07/10/2025 18:58 +02:00
Languages in which this notice is officially available : English
Notice publication number : 00661954-2025
OJ S issue number : 194/2025
Publication date : 09/10/2025