Cryogenic electron microscopy system with 300 kV transmission cryo-electron microscope and cryogenic focused ion beam scanning electron microscope

The Institute of Biotechnology Structural Biology Platform (INSTRUCT-HiLFE) will be upgrading its cryogenic electron microscopy (cryo-EM) services. The current 200 kV transmission electron microscope will be replaced with equipment offering higher resolution for both single-particle and tomography analysis. To enable this, we will establish an integrated workflow for producing samples …

CPV: 38510000 Mikroskopy
Termín:
12. november 2025 10:00
Typ termínu:
Predloženie ponuky
Miesto vykonania:
Cryogenic electron microscopy system with 300 kV transmission cryo-electron microscope and cryogenic focused ion beam scanning electron microscope
Udeľujúci orgán:
University of Helsinki
Číslo udelenia:
577704

1. Buyer

1.1 Buyer

Official name : University of Helsinki
Legal type of the buyer : Body governed by public law
Activity of the contracting authority : Education

2. Procedure

2.1 Procedure

Title : Cryogenic electron microscopy system with 300 kV transmission cryo-electron microscope and cryogenic focused ion beam scanning electron microscope
Description : The Institute of Biotechnology Structural Biology Platform (INSTRUCT-HiLFE) will be upgrading its cryogenic electron microscopy (cryo-EM) services. The current 200 kV transmission electron microscope will be replaced with equipment offering higher resolution for both single-particle and tomography analysis. To enable this, we will establish an integrated workflow for producing samples for tomography and single-particle analysis. Specifically, we will acquire a 300 kV cryogenic transmission electron microscope (cryo-TEM) suitable for high-resolution structural biology, together with a software and hardware compatible cryogenic focused ion beam scanning electron microscope (cryo-FIBSEM) for lamella sample preparation required in high-resolution tomography. The instruments will be installed at the Institute of Biotechnology, University of Helsinki (UH). Delivery and installation will take place in 2027.
Procedure identifier : 5894f967-7322-4e55-bfb2-13627e802a51
Internal identifier : 577704
Type of procedure : Open
The procedure is accelerated : no

2.1.1 Purpose

Main nature of the contract : Supplies
Main classification ( cpv ): 38510000 Microscopes

2.1.2 Place of performance

Country subdivision (NUTS) : Helsinki-Uusimaa ( FI1B1 )
Country : Finland

2.1.3 Value

Estimated value excluding VAT : 5 720 000 Euro

2.1.4 General information

Legal basis :
Directive 2014/24/EU

2.1.6 Grounds for exclusion

Sources of grounds for exclusion : Procurement Document

5. Lot

5.1 Lot technical ID : LOT-0000

Title : Cryogenic electron microscopy system with 300 kV transmission cryo-electron microscope and cryogenic focused ion beam scanning electron microscope
Description : The Institute of Biotechnology Structural Biology Platform (INSTRUCT-HiLFE) will be upgrading its cryogenic electron microscopy (cryo-EM) services. The current 200 kV transmission electron microscope will be replaced with equipment offering higher resolution for both single-particle and tomography analysis. To enable this, we will establish an integrated workflow for producing samples for tomography and single-particle analysis. Specifically, we will acquire a 300 kV cryogenic transmission electron microscope (cryo-TEM) suitable for high-resolution structural biology, together with a software and hardware compatible cryogenic focused ion beam scanning electron microscope (cryo-FIBSEM) for lamella sample preparation required in high-resolution tomography. The instruments will be installed at the Institute of Biotechnology, University of Helsinki (UH). Delivery and installation will take place in 2027.
Internal identifier : 577704

5.1.1 Purpose

Main nature of the contract : Supplies
Main classification ( cpv ): 38510000 Microscopes
Options :
Description of the options : Service contract after the warranty period end.

5.1.2 Place of performance

Country subdivision (NUTS) : Helsinki-Uusimaa ( FI1B1 )
Country : Finland
Additional information :

5.1.3 Estimated duration

Duration : 5 Month

5.1.5 Value

Estimated value excluding VAT : 5 720 000 Euro

5.1.6 General information

Reserved participation : Participation is not reserved.
Procurement Project fully or partially financed with EU Funds.
The procurement is covered by the Government Procurement Agreement (GPA) : yes
This procurement is also suitable for small and medium-sized enterprises (SMEs) : yes

5.1.7 Strategic procurement

Social objective promoted : Human rights due diligence in global supply chains

5.1.9 Selection criteria

Sources of selection criteria : Procurement Document

5.1.10 Award criteria

Criterion :
Type : Price
Name : The total price
Description : The total price must be indicated as a fixed net price excluding VAT (in EUR, VAT 0 %, maximum 5 720 000 euros). The total price must include delivery costs, insurance costs, installation of the equipment so that it is fully operational, the necessary test drives, user and maintenance instructions, training and regular maintenance during the warranty period (total 20 points).
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 20
Criterion :
Type : Quality
Name : Highest number of tomography-based structures obtained using the cryo-TEM instrument or its predecessor at better than 5 Å (0.143 FCS) resolution deposited in EMDB
Description : Highest number of tomography-based structures obtained using the cryo-TEM instrument or its predecessor at better than 5 Å (0.143 FCS) resolution deposited in EMDB.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 10
Criterion :
Type : Quality
Name : Cryo-TEM can be loaded with 10 or more samples at one go.
Description : Cryo-TEM can be loaded with 10 or more samples at one go.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 5
Criterion :
Type : Quality
Name : Cryo-TEM can hold samples at temperature of 90 K or lower inside the microscope
Description : Cryo-TEM can hold samples at temperature of 90 K or lower inside the microscope.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 5
Criterion :
Type : Quality
Name : Sustainability: The current Falcon 4i detector can be installed on the new microscope by the supplier
Description : Sustainability: The current Falcon 4i detector can be installed on the new microscope by the supplier.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 10
Criterion :
Type : Cost
Name : Service contract at fixed price (full service, including unlimited work and parts, and remote support) for an additional four years for both instruments, lowest price
Description : Service contract at fixed price (full service, including unlimited work and parts, and remote support) for an additional four years for both instruments, lowest price .
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 10
Criterion :
Type : Quality
Name : Maximum Cryo-FIBSEM cryo-stage movement range on the x and y axes (x, y range) (largest stage area available
Description : Maximum Cryo-FIBSEM cryo-stage movement range on the x and y axes (x, y range) (largest stage area available.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 5
Criterion :
Type : Quality
Name : Documented use of provider cryo-FIBSEM instrument in tomography applications in at least three peer-reviewed scientific publications with structures reporting resolution better than 8 Å (0.143 FCS)
Description : Documented use of provider cryo-FIBSEM instrument in tomography applications in at least three peer-reviewed scientific publications with structures reporting resolution better than 8 Å (0.143 FCS).
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 5
Criterion :
Type : Quality
Name : 360 degree rotation of the cryo-FIBSEM cryo-stage should be fully continuous in both directions.
Description : 360 degree rotation of the cryo-FIBSEM cryo-stage should be fully continuous in both directions.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 5
Criterion :
Type : Quality
Name : The delivered microscopes come without third-party components.
Description : The delivered microscopes come without third-party components.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 3
Criterion :
Type : Quality
Name : Number of years of extended warranty beyond 1 year provided
Description : Number of years of extended warranty beyond 1 year provided
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 5
Criterion :
Type : Quality
Name : The warranty and extended warranty include automated software to check on daily basis the status of the microscope, a regional customer manager and portal/online access for operational parameters to monitor the system status and history for at least the first 3 years
Description : The warranty and extended warranty include automated software to check on daily basis the status of the microscope, a regional customer manager and portal/online access for operational parameters to monitor the system status and history for at least the first 3 years
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 3
Criterion :
Type : Quality
Name : Cryo-FIBSEM cryo-stage must cool down to at least -170 °C, in less than 30 minutes
Description : Cryo-FIBSEM cryo-stage must cool down to at least -170 °C, in less than 30 minutes
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 5
Criterion :
Type : Quality
Name : Cryo-FIBSEM can hold cryogenic conditions for 20 hours or more without liquid nitrogen dewar refill
Description : Cryo-FIBSEM can hold cryogenic conditions for 20 hours or more without liquid nitrogen dewar refill
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 5
Criterion :
Type : Quality
Name : Viewing of the samples and chamber in FIBSEM instrument should be possible via live cryo-compatible IR CCD camera
Description : Viewing of the samples and chamber in FIBSEM instrument should be possible via live cryo-compatible IR CCD camera
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 4

5.1.11 Procurement documents

Deadline for requesting additional information : 29/10/2025 10:00 +00:00

5.1.12 Terms of procurement

Terms of submission :
Electronic submission : Required
Languages in which tenders or requests to participate may be submitted : English
Electronic catalogue : Not allowed
Tenderers may submit more than one tender : Allowed
Deadline for receipt of tenders : 12/11/2025 10:00 +00:00
Deadline until which the tender must remain valid : 4 Month
Information about public opening :
Opening date : 12/11/2025 10:01 +00:00
Terms of contract :
The execution of the contract must be performed within the framework of sheltered employment programmes : No
A non-disclosure agreement is required : no
Electronic invoicing : Allowed
Electronic ordering will be used : no
Electronic payment will be used : yes

5.1.15 Techniques

Framework agreement :
No framework agreement
Information about the dynamic purchasing system :
No dynamic purchase system

5.1.16 Further information, mediation and review

Review organisation : Markkinaoikeus
Information about review deadlines : A party must request rectification of procurement within 14 days of receiving notice of the decision of the contracting entity (together with instructions for appeal) or of some other resolution made in the procurement procedure. The claim must be submitted by the date when the time limit for submitting a request expires, within office hours. The day of notice is not included in the calculation of the time limit. If the last day for submitting a request is a bank holiday, Independence Day (6 December), the First of May, Christmas Eve, Midsummer Eve or a Saturday, the request for rectification may be submitted on the first weekday following that day, within office hours.

8. Organisations

8.1 ORG-0001

Official name : Markkinaoikeus
Registration number : 3006157-6
Postal address : Radanrakentajantie 5
Town : Helsinki
Postcode : 00520
Country subdivision (NUTS) : Helsinki-Uusimaa ( FI1B1 )
Country : Finland
Telephone : +358 295643300
Roles of this organisation :
Review organisation

8.1 ORG-0002

Official name : University of Helsinki
Registration number : 0313471-7
Postal address : PL 3 (Fabianinkatu 33)
Town : University of Helsinki
Postcode : 00014
Country subdivision (NUTS) : Helsinki-Uusimaa ( FI1B1 )
Country : Finland
Contact point : Hankinnat
Telephone : +358 2941911
Internet address : https://www.helsinki.fi/en
Roles of this organisation :
Buyer

8.1 ORG-0003

Official name : Hansel Oy (Hilma)
Registration number : FI09880841
Postal address : Mannerheiminaukio 1a
Town : Helsinki
Postcode : 00100
Country subdivision (NUTS) : Helsinki-Uusimaa ( FI1B1 )
Country : Finland
Contact point : eSender
Telephone : 029 55 636 30
Roles of this organisation :
TED eSender

Notice information

Notice identifier/version : 0e501372-7700-4a8e-80fe-5186243dd63b - 01
Form type : Competition
Notice type : Contract or concession notice – standard regime
Notice dispatch date : 13/10/2025 08:32 +00:00
Notice dispatch date (eSender) : 13/10/2025 08:33 +00:00
Languages in which this notice is officially available : English
Notice publication number : 00674904-2025
OJ S issue number : 197/2025
Publication date : 14/10/2025