Procurement of spectrofluorometer

Mutations in the archetypal Ca2+-sensor calmodulin (CaM) are associated with life-threat-ening cardiac arrhythmias in children. Yet, population wide sequencing studies now reveal carriers of CaM mutations who are seemingly healthy. This extreme segregation of phenotypes warrants a deeper understanding of the molecular impact of CaM mutations, to understand why some …

CPV: 38433000 Спектрометри
Краен срок:
Септ. 22, 2025, 10 след обяд
Вид на крайния срок:
Подаване на оферта
Място на изпълнение:
Procurement of spectrofluorometer
Издаващ орган:
Aalborg Universitet
Номер на наградата:
29317dc1-931a-4f11-b23c-c77ba14059b8

1. Buyer

1.1 Buyer

Official name : Aalborg Universitet
Legal type of the buyer : Organisation awarding a contract subsidised by a central government authority
Activity of the contracting authority : Education

2. Procedure

2.1 Procedure

Title : Procurement of spectrofluorometer
Description : Mutations in the archetypal Ca2+-sensor calmodulin (CaM) are associated with life-threat-ening cardiac arrhythmias in children. Yet, population wide sequencing studies now reveal carriers of CaM mutations who are seemingly healthy. This extreme segregation of phenotypes warrants a deeper understanding of the molecular impact of CaM mutations, to understand why some variants result in a pathogenic phenotype and other variants do not. Thus, the aim of this project is to determine which human Calmodulin mutations impair the ability to bind Ca2+-ions and decode intracellular Ca2+-signals to target proteins. We wish to upgrade our experimental platform with a new spectrofluorometer for measuring the Ca2+-affinity of CaM variants. Calcium binding to the CaM N- and C-lobe can be followed by intrinsic Phe and Tyr fluorescence, respectively. The change in fluorescence signal upon Ca2+-binding is small and demands high sensitivity and spectral specificity to be accurately and reliably measured. The optical configuration of the spectrofluorometer we seek needs to meet these requirements. The instrument should further be equipped with a fluorescence anisotropy module to enable characterization of CaM binding to TAMRA-labeled CaM-binding domains from target proteins.
Procedure identifier : 22a9f2bd-196d-4bc0-a884-0659adc71e26
Internal identifier : 29317dc1-931a-4f11-b23c-c77ba14059b8
Type of procedure : Other single stage procedure

2.1.1 Purpose

Main nature of the contract : Supplies
Additional nature of the contract : Services
Main classification ( cpv ): 38433000 Spectrometers

2.1.2 Place of performance

Country subdivision (NUTS) : Nordjylland ( DK050 )
Country : Denmark

2.1.4 General information

Legal basis :
Directive 2014/24/EU

2.1.6 Grounds for exclusion

Sources of grounds for exclusion : Procurement Document

5. Lot

5.1 Lot technical ID : LOT-0000

Title : Procurement of spectrofluorometer
Description : Mutations in the archetypal Ca2+-sensor calmodulin (CaM) are associated with life-threat-ening cardiac arrhythmias in children. Yet, population wide sequencing studies now reveal carriers of CaM mutations who are seemingly healthy. This extreme segregation of phenotypes warrants a deeper understanding of the molecular impact of CaM mutations, to understand why some variants result in a pathogenic phenotype and other variants do not. Thus, the aim of this project is to determine which human Calmodulin mutations impair the ability to bind Ca2+-ions and decode intracellular Ca2+-signals to target proteins. We wish to upgrade our experimental platform with a new spectrofluorometer for measuring the Ca2+-affinity of CaM variants. Calcium binding to the CaM N- and C-lobe can be followed by intrinsic Phe and Tyr fluorescence, respectively. The change in fluorescence signal upon Ca2+-binding is small and demands high sensitivity and spectral specificity to be accurately and reliably measured. The optical configuration of the spectrofluorometer we seek needs to meet these requirements. The instrument should further be equipped with a fluorescence anisotropy module to enable characterization of CaM binding to TAMRA-labeled CaM-binding domains from target proteins.
Internal identifier : 3119c93d-9fbf-403d-b7ec-39ab71098a05

5.1.1 Purpose

Main nature of the contract : Supplies
Additional nature of the contract : Services
Main classification ( cpv ): 38433000 Spectrometers

5.1.2 Place of performance

Country subdivision (NUTS) : Nordjylland ( DK050 )
Country : Denmark
Additional information :

5.1.3 Estimated duration

Start date : 15/10/2025
Duration end date : 15/12/2025

5.1.6 General information

Reserved participation : Participation is not reserved.
Procurement Project not financed with EU Funds.
The procurement is covered by the Government Procurement Agreement (GPA) : yes

5.1.9 Selection criteria

Sources of selection criteria : Procurement Document

5.1.11 Procurement documents

5.1.12 Terms of procurement

Terms of submission :
Electronic submission : Required
Languages in which tenders or requests to participate may be submitted : English
Electronic catalogue : Not allowed
Deadline for receipt of tenders : 22/09/2025 22:00 +00:00
Terms of contract :
The execution of the contract must be performed within the framework of sheltered employment programmes : No
Electronic invoicing : Required
Electronic ordering will be used : yes
Electronic payment will be used : yes

5.1.15 Techniques

Framework agreement :
No framework agreement
Information about the dynamic purchasing system :
No dynamic purchase system

5.1.16 Further information, mediation and review

Review organisation : Klagenævnet for Udbud
Organisation providing more information on the review procedures : Konkurrence- og Forbrugerstyrelsen

8. Organisations

8.1 ORG-0001

Official name : Aalborg Universitet
Registration number : 29102384
Postal address : Fredrik Bajers Vej 7K
Town : Aalborg Øst
Postcode : 9220
Country subdivision (NUTS) : Nordjylland ( DK050 )
Country : Denmark
Contact point : Alexander Herskind Rasmussen
Telephone : 22505186
Roles of this organisation :
Buyer

8.1 ORG-0002

Official name : Klagenævnet for Udbud
Registration number : 37795526
Postal address : Toldboden 2
Town : Viborg
Postcode : 8800
Country subdivision (NUTS) : Vestjylland ( DK041 )
Country : Denmark
Contact point : Klagenævnet for Udbud
Telephone : +45 72405600
Roles of this organisation :
Review organisation

8.1 ORG-0003

Official name : Konkurrence- og Forbrugerstyrelsen
Registration number : 10294819
Postal address : Carl Jacobsens Vej 35
Town : Valby
Postcode : 2500
Country subdivision (NUTS) : Byen København ( DK011 )
Country : Denmark
Contact point : Konkurrence- og Forbrugerstyrelsen
Telephone : +45 41715000
Information exchange endpoint (URL) : https://www.kfst.dk
Roles of this organisation :
Organisation providing more information on the review procedures

8.1 ORG-0004

Official name : Mercell Holding ASA
Registration number : 980921565
Postal address : Askekroken 11
Town : Oslo
Postcode : 0277
Country subdivision (NUTS) : Oslo ( NO081 )
Country : Norway
Contact point : eSender
Telephone : +47 21018800
Fax : +47 21018801
Internet address : http://mercell.com/
Roles of this organisation :
TED eSender

Notice information

Notice identifier/version : 078b6cd5-4089-4829-b717-059afe97c273 - 01
Form type : Competition
Notice type : Contract or concession notice – standard regime
Notice dispatch date : 03/09/2025 11:51 +00:00
Notice dispatch date (eSender) : 03/09/2025 12:05 +00:00
Languages in which this notice is officially available : English
Notice publication number : 00578331-2025
OJ S issue number : 169/2025
Publication date : 04/09/2025