Confocal Microscope

The Leiden Academic Centre for Drug Research (LACDR) (part of the Faculty of Science of Leiden University) is seeking tenders for the procurement of one advanced microscope capable of performing image-guided single-cell sampling and isolation using confocal imaging and lifetime fluorescence. The microscope will be used for the Exposome Scan …

CPV: 38510000 Microscopi, 38634000 Microscopi ottici
Scadenza:
Giovedì 04 Settembre 2025 10:00
Tipo di scadenza:
Presentazione di un'offerta
Luogo di esecuzione:
Confocal Microscope
Ente di assegnazione:
Universiteit Leiden
Numero di premio:

1. Buyer

1.1 Buyer

Official name : Universiteit Leiden
Legal type of the buyer : Body governed by public law
Activity of the contracting authority : Education

2. Procedure

2.1 Procedure

Title : Confocal Microscope
Description : The Leiden Academic Centre for Drug Research (LACDR) (part of the Faculty of Science of Leiden University) is seeking tenders for the procurement of one advanced microscope capable of performing image-guided single-cell sampling and isolation using confocal imaging and lifetime fluorescence. The microscope will be used for the Exposome Scan Dutch infrastructure and located at the Leiden Cell Observatory (LCO). With this microscope we aim to develop a microscopy-based infrastructure that enables both i) high-throughput phenotypic screening in 3D live advanced cell systems and ii) image-guided single-cell and intracellular component sampling. This infrastructure will serve scientists interested in screening relevant compound libraries in a wide variety of advanced fluorescent reporter cell systems (e.g., human stem cells cultured in 2D and differentiated in 3D microtissues such as liver or kidney organoids) and obtaining a mechanistic understanding of specific imaged phenotypes using a multi-omics approach. The microscope hardware must provide the following functionality: 1) Hardware: Label-free (brightfield or transmission), and lifetime microscopy. Time-lapse microscopy (incubator for a controlled environment). Confocal microscopy for 2D and 3D reporter cell systems cultured in multi-well plates. Automated high-content microscopy (automated stage with high X, Y, Z accuracy for both screening and automated micro sampling). High reproducibility in Z focus needed for time-lapse 2D/3D microscopy (perfect focus/autofocus). 2) Software: Software must be able to communicate with third-party software controlling the micro-sampling robotic. Smart microscopy functionality that allows the automated detection of single-cell events such as: Recognition of intracellular organelles or parts of the cytoplasm. Recognition of a cell next to a target cell. Recognition of cells with different morphologies. Recognition of cells or intracellular components with different lifetime signals. Recognition of specific cell regions based on different fluorescent lifetime signals. Single-cell cloning from cells displaying a unique phenotype. 4) FAIR Compliance: Imaging data must comply with the FAIR principles, including compatibility with the OMERO database and preferentially generating OME-ZARR standards. The microscope must have state-of-the-art reliability and be compatible with Dutch work environment safety regulations (ARBO).
Procedure identifier : a36c081e-6a37-42df-abd2-c71120e97d7c
Type of procedure : Open
The procedure is accelerated : no

2.1.1 Purpose

Main nature of the contract : Supplies
Main classification ( cpv ): 38510000 Microscopes
Additional classification ( cpv ): 38634000 Optical microscopes

2.1.2 Place of performance

Town : Leiden
Country subdivision (NUTS) : Agglomeratie Leiden en Bollenstreek ( NL363 )
Country : Netherlands
Additional information : See documentation

2.1.3 Value

Estimated value excluding VAT : 495 867,77 Euro

2.1.4 General information

Legal basis :
Directive 2014/24/EU

2.1.6 Grounds for exclusion

Sources of grounds for exclusion : Notice
Corruption : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Fraud : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Money laundering or terrorist financing : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Participation in a criminal organisation : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Terrorist offences or offences linked to terrorist activities : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Child labour and including other forms of trafficking in human beings : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Breaching of obligations in the fields of environmental law : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Breaching of obligations in the fields of labour law : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Breaching of obligations in the fields of social law : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Agreements with other economic operators aimed at distorting competition : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Misrepresentation, withheld information, unable to provide required documents and obtained confidential information of this procedure : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Offence concerning its professional conduct in the domain of defence procurement : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Conflict of interest due to its participation in the procurement procedure : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Direct or indirect involvement in the preparation of this procurement procedure : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Early termination, damages, or other comparable sanctions : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Lack of reliability to exclude risks to the security of the country : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Breaching obligation relating to payment of social security contributions : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Breaching obligation relating to payment of taxes : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Business activities are suspended : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Bankruptcy : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Arrangement with creditors : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Insolvency : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Assets being administered by liquidator : Paragraaf 2.3.5.1 Aanbestedingswet 2012
Analogous situation like bankruptcy, insolvency or arrangement with creditors under national law : Paragraaf 2.3.5.1 Aanbestedingswet 2012

5. Lot

5.1 Lot technical ID : LOT-0000

Title : Confocal Microscope
Description : The Leiden Academic Centre for Drug Research (LACDR) (part of the Faculty of Science of Leiden University) is seeking tenders for the procurement of one advanced microscope capable of performing image-guided single-cell sampling and isolation using confocal imaging and lifetime fluorescence. The microscope will be used for the Exposome Scan Dutch infrastructure and located at the Leiden Cell Observatory (LCO). With this microscope we aim to develop a microscopy-based infrastructure that enables both i) high-throughput phenotypic screening in 3D live advanced cell systems and ii) image-guided single-cell and intracellular component sampling. This infrastructure will serve scientists interested in screening relevant compound libraries in a wide variety of advanced fluorescent reporter cell systems (e.g., human stem cells cultured in 2D and differentiated in 3D microtissues such as liver or kidney organoids) and obtaining a mechanistic understanding of specific imaged phenotypes using a multi-omics approach. The microscope hardware must provide the following functionality: 1) Hardware: Label-free (brightfield or transmission), and lifetime microscopy. Time-lapse microscopy (incubator for a controlled environment). Confocal microscopy for 2D and 3D reporter cell systems cultured in multi-well plates. Automated high-content microscopy (automated stage with high X, Y, Z accuracy for both screening and automated micro sampling). High reproducibility in Z focus needed for time-lapse 2D/3D microscopy (perfect focus/autofocus). 2) Software: Software must be able to communicate with third-party software controlling the micro-sampling robotic. Smart microscopy functionality that allows the automated detection of single-cell events such as: Recognition of intracellular organelles or parts of the cytoplasm. Recognition of a cell next to a target cell. Recognition of cells with different morphologies. Recognition of cells or intracellular components with different lifetime signals. Recognition of specific cell regions based on different fluorescent lifetime signals. Single-cell cloning from cells displaying a unique phenotype. 4) FAIR Compliance: Imaging data must comply with the FAIR principles, including compatibility with the OMERO database and preferentially generating OME-ZARR standards. The microscope must have state-of-the-art reliability and be compatible with Dutch work environment safety regulations (ARBO).

5.1.1 Purpose

Main nature of the contract : Supplies
Main classification ( cpv ): 38510000 Microscopes
Additional classification ( cpv ): 38634000 Optical microscopes

5.1.2 Place of performance

Town : Leiden
Country subdivision (NUTS) : Agglomeratie Leiden en Bollenstreek ( NL363 )
Country : Netherlands
Additional information : See documentation

5.1.3 Estimated duration

Duration : 12 Month

5.1.5 Value

Estimated value excluding VAT : 495 867,77 Euro

5.1.6 General information

Reserved participation : Participation is not reserved.
Procurement Project not financed with EU Funds.
The procurement is covered by the Government Procurement Agreement (GPA) : yes
This procurement is also suitable for small and medium-sized enterprises (SMEs) : yes

5.1.7 Strategic procurement

5.1.10 Award criteria

Criterion :
Type : Quality
Name : High-throughput Imaging instruments
Description : The instrument should be equipped with an automatic water dispenser system for keeping the immersion liquid on the objectives. Imaging speed at full FOV 100 fps Automatic correction collar that can be adjusted automatically for best optical performance via software without user’s manual input.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 25
Criterion :
Type : Quality
Name : Readiness for integration with automated microsampling in multiwell plate
Description : High-precision motorized stage with sub-micron accuracy in XYZ axes for exact positioning of the sampling needle XYZ axial designated resolution: 0.1μm Willingness to modify/open software to accommodate the microsampler Compatible with integration of needle control software with the confocal microscope control software for coordinated movements. Compatible with real-time imaging feedback to ensure correct needle placement during sampling.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 40
Criterion :
Type : Quality
Name : Data Generation and FAIR Data Management
Description : Software should generate OME.zarr, the Next Generation File Format (NGFF) for bioimaging data Software capable of directly interfacing with the OMERO server for data storage, annotation, and sharing. Software should allow for the automatic upload of imaging data and metadata to the OMERO server without requiring manual intervention.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 20
Criterion :
Type : Quality
Name : Service and Warranty Requirements
Description : Comprehensive user training must be provided on-site at the time of installation. This should include hands-on training for operating the microscope, basic troubleshooting, and maintenance procedures. Detailed user manuals, maintenance guides, and troubleshooting documentation must be provided in both printed and electronic formats. The vendor must provide all software updates and upgrades free of charge. Updates should include new features, security patches, and performance improvements. The vendor should offer options for extending the warranty and service contracts beyond the initial warranty period. Details of extended warranty plans, including costs and coverage, should be provided.
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 25
Criterion :
Type : Price
Name : Price
Description : Price of the microscope
Category of award threshold criterion : Weight (points, exact)
Award criterion number : 160

5.1.11 Procurement documents

Address of the procurement documents : https://s2c.mercell.com/today/163390

5.1.12 Terms of procurement

Terms of submission :
Electronic submission : Allowed
Languages in which tenders or requests to participate may be submitted : English
Electronic catalogue : Not allowed
Variants : Not allowed
Tenderers may submit more than one tender : Not allowed
Deadline for receipt of tenders : 04/09/2025 10:00 +00:00
Deadline until which the tender must remain valid : 90 Day
Information about public opening :
Opening date : 04/09/2025 10:05 +00:00
Place : Elektronically
Terms of contract :
The execution of the contract must be performed within the framework of sheltered employment programmes : No
A non-disclosure agreement is required : no
Electronic invoicing : Allowed
Electronic ordering will be used : no
Electronic payment will be used : yes

5.1.15 Techniques

Framework agreement :
No framework agreement
Information about the dynamic purchasing system :
No dynamic purchase system

5.1.16 Further information, mediation and review

Review organisation : Rechtbank Den Haag
Information about review deadlines : Within 20 days after contract-award decision.

8. Organisations

8.1 ORG-0001

Official name : Universiteit Leiden
Registration number : 27368929
Postal address : Kolffpad 1
Town : Leiden
Postcode : 2333BN
Country subdivision (NUTS) : Agglomeratie Leiden en Bollenstreek ( NL363 )
Country : Netherlands
Contact point : Govert Schipperheijn
Telephone : +31715273304
Roles of this organisation :
Buyer

8.1 ORG-0002

Official name : Rechtbank Den Haag
Registration number : 82946175
Department : Civiel
Postal address : Postbus 20303
Town : Den Haag
Postcode : 2500 EH
Country subdivision (NUTS) : Agglomeratie ’s-Gravenhage ( NL361 )
Country : Netherlands
Contact point : Informatie
Telephone : +31883622200
Roles of this organisation :
Review organisation

Notice information

Notice identifier/version : 07f82639-b8a6-45b7-8c08-4396c0fa7ff6 - 01
Form type : Competition
Notice type : Contract or concession notice – standard regime
Notice dispatch date : 16/07/2025 13:01 +00:00
Notice dispatch date (eSender) : 16/07/2025 13:02 +00:00
Languages in which this notice is officially available : English
Notice publication number : 00470442-2025
OJ S issue number : 136/2025
Publication date : 18/07/2025